Overview


According to FutureWise analysis, the market for KRAS Inhibitors is expected to grow with a CAGR of 5.2% over the forecast period 2024-2032, and reach a market value of US$ 0.15 billion by 2031.

KRAS (Kirsten rat sarcoma viral oncogene homolog) inhibitor is a gene that delivers instructions for making a protein involved in cell signaling pathways. Mutations in the KRAS gene are frequently found in different types of cancer, such as lung, colorectal, and pancreatic cancer. These mutations can lead to uncontrolled cell development and the development of tumors. KRAS inhibitors are a class of drugs designed to specifically target the mutated KRAS protein or its associated signaling pathways. These drugs aim to disrupt the abnormal cellular signaling caused by the mutated KRAS gene, ultimately hindering the development and spread of cancer cells.

KRAS genes are usually found in different types of cancer, including lung, colorectal, and pancreatic cancer. In lung cancer, which often harbors KRAS mutations, inhibitors targeting this oncogene have shown significant potential. These inhibitors disrupt the aberrant signaling pathways activated by mutant KRAS, thereby impeding tumor growth and progression. Similarly, in pancreatic cancer, where KRAS mutations are nearly ubiquitous, developing KRAS inhibitors has been important. Pancreatic cancer patients with KRAS mutations represent a substantial portion of cases, and targeted therapies aimed at this specific mutation have shown encouraging results in preclinical and early clinical trials. Colorectal cancer is another malignancy in which KRAS mutations play a critical role. In this context, KRAS inhibitors have shown promise in suppressing the growth of tumors driven by these mutations. They function by interrupting the signaling cascades initiated by mutant KRAS, ultimately curbing the proliferation of cancerous cells.

FutureWise Market Research has published a report that provides an insightful analysis KRAS inhibitors market trends that are affecting the overall market growth. This report will provide a detailed analysis of market share, regional insights, and competitor analysis that includes stature of key manufacturers operational in this industry. According to the analysis conducted by FutureWise research analysts KRAS inhibitors market estimated to register a considerable growth rate over the forecast period. This report lists the market segments and potential prospects available across this industry, in addition providing crucial information on the total valuation currently held by the industry. Moreover, this report will assist key management individuals in an organisation to enhance their decisions pertaining to business expansion as well as strategic changes for increasing customer base.

  • Amgen
  • Boehringer Ingelheim
  • BridgeBio Pharma
  • Erasca
  • Innovent Biologics, Inc.
  • Incyte
  • Mirati Therapeutics
  • Novartis
  • Jemincare
  • Cardiff Oncology, Inc.

(Note: The list of the major players will be updated with the latest market scenario and trends)

Recent Developments in KRAS Inhibitors Market:

  • In April 2023, Innovent Biologics, Inc. unveiled the latest findings of the phase 1 clinical trial (NCT05005234) for IBI351 (GFH925), a KRASG12C inhibitor. These updated results were presented at the 2023 Annual Meet of the American Association for Cancer Research (AACR).
  • In February 2021, Mirati Therapeutics and the University of Texas MD Anderson Cancer Center, Inc. jointly announced a strategic collaboration in research and development. The collaboration aims to broaden the assessment of Mirati's two investigational KRAS inhibitors - adagrasib (MRTX849) in clinical development and MRTX1133 in preclinical development. These inhibitors, which target two commonly occurring KRAS mutations in cancer, will be evaluated both as monotherapy and in combination with other agents.

The rising prevalence of KRAS mutations across various types of cancers, including colorectal, lung, and pancreatic malignancies, is expected to drive the growth of KRAS inhibitors. As comprehension of KRAS's intricate signaling pathways aggravates, it elucidates its significance as a prime therapeutic target. This expanding knowledge base fuels a heightened demand for potent KRAS inhibitors, driven by the imperative to develop targeted therapies tailored to combat the specific genetic underpinnings of these diverse cancers. This increase in interest is paralleled by a burgeoning pipeline of innovative compounds and therapeutic approaches, reflecting a promising trajectory in oncology. Moreover, ongoing research into the molecular mechanisms of cancer, including the role of KRAS, is driving the development of targeted therapies like KRAS inhibitors. This revelation has ignited a surge in research efforts, driving the development of precisely tailored therapies like KRAS inhibitors. With an ever-deepening understanding, scientists unravel the subtle interactions within cellular pathways, providing crucial insights that are harnessed to design innovative inhibitors. This continuous exploration not only solidifies KRAS as a critical target but also propels the evolution of targeted therapies, promising more effective and personalized treatments for cancer patients. Also, the synergistic potential of integrating KRAS inhibitors with a multifaceted approach to cancer treatment holds immense promise in revolutionizing patient outcomes. By strategically combining these inhibitors with other targeted therapies, immunomodulatory interventions, or established treatment modalities, clinicians may tackle cancer from multiple angles, potentially overcoming resistance mechanisms and enhancing overall efficacy, thus propelling the KRAS inhibitors market growth. However, the complexity of KRAS as a signaling protein presents a significant challenge in developing effective inhibitors. Its diverse isoforms and intricate downstream signaling pathways demand a profound understanding of targeted intervention. This complexity amplifies the hurdles in drug development, necessitating extensive research and innovation to navigate this intricate terrain. Also, cancer's remarkable adaptability is exemplified in its ability to develop resistance to targeted therapies, including KRAS inhibitors. This resistance phenomenon poses a substantial obstacle, compelling researchers to explore novel strategies to circumvent and overcome these adaptive mechanisms, thereby heightening the difficulty in creating enduring and efficacious treatments for KRAS-driven malignancies.

By Cancer Type

  • Lung Cancer
  • Pancreatic Cancer
  • Colorectal Cancer
  • Others

By End-Use

  • Clinic Laboratories
  • Cancer Diagnostic Centers
  • Hospitals
  • Cancer Research Institutes
  • Academic Institutions
  • Others

By Region

  • North America
  • Europe
  • Asia-Pacific
  • Latin America
  • Middle East and Africa

This market research report also emphasis on factors affecting the growth rate in various regions listed above. A deep-down analysis of region will also be provided in the final version of this market which is based on conclusion of primary interviews and secondary data point gathered during the process.

By region, the market is segmented into North America, Latin America, Europe, Asia-Pacific, and Middle East & Africa. North America registered highest revenue share in the market in 2022. Owing to the growing demand for targeted therapies in oncology, advancement in research and development, advanced healthcare infrastructure, rising prevalence of KRAS mutations in various types of cancers, and advancements in drug discovery and development are likely to fuel the market growth in the area. For instance, it is estimated that in 2023, approximately 238,340 adults (117,550 men and 120,790 women) will acquire a lung cancer diagnosis in the US alone. Additionally, rising government investments, biotechnological advancements, and the digitalization of health profiles have also propelled the target market. Also, the presence of key players, acquisition, partnership, and collaboration are factors driving the market growth in the US over the forecast period.

  • Tier 1 players- established companies in the market with a major market share
  • Tier 2 players
  • Emerging players which are growing rapidly
  • New Entrants

  • Growth prospects
  • SWOT analysis
  • Key trends
  • Key data-points affecting market growth

  • To provide with an exhaustive analysis on the KRAS Inhibitors Market By Cancer Type, By End-Use, and By Region
  • To cater comprehensive information on factors impacting market growth (drivers, restraints, opportunities, and industry-specific restraints)
  • To evaluate and forecast micro-markets and the overall market
  • To predict the market size, in key regions— North America, Europe, Asia Pacific, Latin America and Middle East and Africa.
  • To record and evaluate competitive landscape, mapping- product launches, technological advancements, mergers and expansions

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Table of Contents


  • 1.  Market Introduction
    •   1. Objectives of the Study 
        2. Market Definition 
        3. Market Scope 
           3.1. Years Considered for the Study
           3.2. Market Covered
        4. Currency 
        5. Limitations 
        6. Stakeholders 

  • 2.  Research Methodology
    •   1 Research Data 
           1.1. Secondary Data
              1.1.1. Key Data from Secondary Sources
           1.2 Primary Data
              1.2.1. Key Data from Primary Sources
        3.Market Size Estimation 
        4. Market Breakdown and Data Triangulation 
        5. Assumptions for the Study 

  • 3.  Executive Summary
    •   1. Market Outlook
        2. Segment Outlook
        3. Competitive Insights

  • 4.  KRAS Inhibitors Market Variables, Trends & Scope
    •   1. Market Lineage Outlook
        2. Penetration and Growth Prospect Mapping
        3. Industry Value Chain Analysis
        4. Cost Analysis Breakdown
        5. Application Overview
        6. Regulatory Framework
           6.1. Reimbursement Framework
           6.2. Standards and Compliances

  • 5.  Market Overview
    •   1. Market Dynamics
           1.1. Market Driver Analysis
              1.1.1. Increasing focus of KRAS Inhibitors Market Companies on Brand Protection
              1.1.2. Untapped Opportunities in Emerging Regions
           1.2. Market Restraint Analysis
              1.2.1. High Cost Associated with Implementation of Predictive Analysis
           1.3. Industry Challenges
              1.3.1. Presence of Ambiguous Regulatory Framework

  • 6.  KRAS Inhibitors Market Analysis Tools
    •   1. Industry Analysis - Porter’s
           1.1. Supplier Power
           1.2. Buyer Power
           1.3. Substitution Threat
           1.4. Threat from New Entrants
           1.5. Competitive Rivalry
        2. Pestel Analysis
           2.1. Political Landscape
           2.2. Environmental Landscape
           2.3. Social Landscape
           2.4. Application Landscape
           2.5. Legal Landscape
        3. Major Deals And Strategic Alliances Analysis
           3.1. Joint Ventures
           3.2. Mergers and Acquisitions
           3.3. Licensing and Partnership
           3.4. Application Collaborations
           3.5. Strategic Divestments
        4. Market Entry Strategies
        5. Case Studies

  • 7.  KRAS Inhibitors Market, By Cancer Type Historical Analysis and Forecast 2024-2032 (USD Million)
      1. Lung Cancer
      2. Pancreatic Cancer
      3. Colorectal Cancer
      4. Others
         
  • 8.  KRAS Inhibitors Market, By End-Use Historical Analysis and Forecast 2024-2032 (USD Million)
      1. Clinic Laboratories
      2. Cancer Diagnostic Centers
      3. Hospitals
      4. Cancer Research Institutes
      5. Academic Institutions
      6. Others
         
  • 9.  North America KRAS Inhibitors Market Analysis 2018-2023 and Forecast 2024-2032 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2023
           2.1. U.S.A
           2.2. Canada
           2.3. Mexico
        3. Market Size (USD Million) Forecast for North America 2024-2032

  • 10.  Latin America KRAS Inhibitors Market Analysis 2018-2023 and Forecast 2024-2032 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2023
           2.1. Brazil
           2.2. Venezuela
           2.3. Argentina
           2.4. Rest of Latin America
        3. Market Size (USD Million) Forecast for Latin America 2024-2032

  • 11.  Europe KRAS Inhibitors Market Analysis 2018-2023 and Forecast 2024-2032 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2023
           2.1. Germany
           2.2. U.K
           2.3. France
           2.4. Italy
           2.5. Spain
           2.6. Russia
           2.7. Poland
           2.8. Rest of Europe
        3. Market Size (USD Million) Forecast for Europe 2024-2032

  • 12.  Asia Pacific KRAS Inhibitors Market Analysis 2018-2023 and Forecast 2024-2032 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2023
           2.1. Japan
           2.2. China
           2.3. India
           2.4. Australia and New Zealand
           2.5. ASEAN
           2.6. Rest of Asia Pacific
        3. Market Size (USD Million) Forecast for Asia Pacific 2024-2032

  • 13.  Middle East and Africa Market Analysis 2018-2023 and Forecast 2024-2032 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2023
           2.1. GCC
           2.2. Israel
           2.3. South Africa
           2.4. Rest of MEA
        3. Market Size (USD Million) Forecast for MEA 2024-2032

  • 14.  Market Share Analysis and Competitive Landscape
    •   1. Global Landscape - Key Players, Revenue and Presence
        2. Global Share Analysis - Key Players (Tier 1, Tier 2, Tier 3)
        3. Global Emerging Companies
        4. North America - Market Share Analysis and Key Regional Players
        5. Europe - Market Share Analysis and Key Regional Players
        6. Asia Pacific - Market Share Analysis and Key Regional Players
        7. Global Key Player - Growth Matrix

  • 15.  Company Profiles (Competition Dashboard, Competitors Deep Dive, Product Type and Technology Portfolio, Financial Layouts)
    •   1. Amgen
           1.1. Company Overview
           1.2. Product Portfolio
           1.3. SWOT Analysis
           1.4. Financial Overview
           1.5. Strategic Overview
        2. Boehringer Ingelheim
           2.1. Company Overview
           2.2. Product Portfolio
           2.3. SWOT Analysis
           2.4. Financial Overview
           2.5. Strategic Overview
        3. BridgeBio Pharma
           3.1. Company Overview
           3.2. Product Portfolio
           3.3. SWOT Analysis
           3.4. Financial Overview
           3.5. Strategic Overview
        4. Erasca
           4.1. Company Overview
           4.2. Product Portfolio
           4.3. SWOT Analysis
           4.4. Financial Overview
           4.5. Strategic Overview
        5. Innovent Biologics, Inc.
           5.1. Company Overview
           5.2. Product Portfolio
           5.3. SWOT Analysis
           5.4. Financial Overview
           5.5. Strategic Overview
        6. Incyte
           6.1. Company Overview
           6.2. Product Portfolio
           6.3. SWOT Analysis
           6.4. Financial Overview
           6.5. Strategic Overview
        7. Mirati Therapeutics
           7.1. Company Overview
           7.2. Product Portfolio
           7.3. SWOT Analysis
           7.4. Financial Overview
           7.5. Strategic Overview
        8. Novartis
           8.1. Company Overview
           8.2. Product Portfolio
           8.3. SWOT Analysis
           8.4. Financial Overview
           8.5. Strategic Overview
        9. Jemincare
           9.1. Company Overview
           9.2. Product Portfolio
           9.3. SWOT Analysis
           9.4. Financial Overview
           9.5. Strategic Overview
        10. Cardiff Oncology, Inc.
           10.1. Company Overview
           10.2. Product Portfolio
           10.3. SWOT Analysis
           10.4. Financial Overview
           10.5. Strategic Overview

  • 16.  Pre and Post COVID-19 Impact
    •   1. Positive influence on the healthcare industry
        2. The financial disruption of the manufacturing sector
        3. Impact of COVID-19 on emerging companies
        4. Significant mandates in the healthcare regulations initiated by
            administrations
        5. The overall economic slowdown of the developing and developed nations

  • 17.  FutureWise SME Key Takeaway Points for Client
    •   

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