Overview


According to FutureWise analysis the market for in vivo toxicology is expected to reach US$ 9.21 billion by 2031 at a CAGR of 5.72%.

In vivo, toxicology is the study of the toxic effect of certain drugs on living organisms. In vivo, toxicology focuses on the route of new investigative medicines (IND) administration. The capacity of a drug to reach its target in a living system can unintentionally be deterred by immune system mechanisms, metabolic processes, and similar natural mechanisms. This is the problem faced following in vitro studies in which INDs no longer directly target the desired cells but face a living biological system in which their target is one of many. As a result, various drug administration routes are explored to determine toxicity and benefits when such routes are taken. Evaluation of drug administration routes should anticipate clinical results and optimize beneficial efficacy. Toxicology studies include acute, subchronic, and chronic toxicity tests. Acute toxicology studies focus on the toxicological effects following a single large dose of the substance of interest. For longer-term studies, subchronic and chronic studies simulate the long-term use of the drugs and their subsequent adverse effects. Subchronic toxicology studies include repeated small dosages of the test substance over some time up to 90 days. At the same time, chronic toxicology studies focus on the test substance's long-term effects over months to years. Implications of these toxicology studies can lead to a phase 1 clinical trial should the test substance show promising results and minimal toxicological, carcinogenic, and mutagenic effects.

FutureWise Market Research has published a report that provides an insightful analysis of In Vivo Toxicology market trends affecting overall market growth. This report will provide a detailed analysis of market share, regional insights, and competitor analysis that includes the stature of key manufacturers operational in this industry.

According to the analysis conducted by FutureWise research analysts, the In Vivo Toxicology market is estimated to register a substantial growth rate over the forecast period. This report lists the market segments and potential prospects available across this industry, in addition to providing crucial information on the total valuation currently held by the industry. Moreover, this report will assist key management individuals in an organization to enhance their decisions on business expansion and strategic changes for increasing customer base.

  • Thermo Fisher Scientific
  • Danaher
  • Charles River Laboratories
  • LabCorp 
  • The Jackson Laboratory
  • Data Sciences International
  • Envigo 
  • Eurofins Scientific
  • PerkinElmer
  • SRI International 
  • Taconic Biosciences
  • Wuxi Apptec

(Note: The list of the major players will be updated with the latest market scenario and trends)

Recent Developments in the In Vivo Toxicology Market:

  • In September 2021- Charles River Laboratories declared the launch of a novel testing platform for the detection of residual host cells (HCDNA) within biological drugs. This platform, called In-Vivo DNA Clearance, will offer biopharmaceutical companies to ensure their product's purity and safety.
  • ·In September 2021 - Shimadzu introduced the new MALDI-TOF mass spectrometer, called the MALDImini-1. This cutting-edge instrument facilitates rapid and accurate analysis of small molecules in various fields, such as clinical diagnostics and drug discovery applications.

By Product

  • Instruments
  • Consumables
    • Reagents and Kits
    • Animal Models
      • Mice Models
      • Rat Models
      • Other Animal Models (Guinea Pigs, Hamsters, Rabbits, and Human Primates)

By Test Type

  • Acute
  • Sub-acute
  • Sub-chronic
  • Chronic test type

By Testing facility

  • Outsourced testing facility
  • In-house testing facility

By Toxicity End Point

  • Immunotoxicity
  • Systemic toxicity
  • Carcinogenicity
  • Genotoxicity
  • Developmental and reproductive toxicity (DART)
  • Other toxicity endpoints

By End User

  • Academic and Research Institutes
  • Pharmaceutical and Biotechnology Companies
  • Contract Research Organizations
  • Other End Users

By Region

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East and Africa

The market is segmented by region into North America, Latin America, Europe, Asia-Pacific, and Middle East & Africa. North America registered the highest share in the market in 2022. The year 2022 witnessed over 236,000 lung cancer cases diagnosed in the United States. The rising number of cancer cases spurred a growing demand for innovative drug discovery and treatment strategies. To address this, in-vivo toxicology testing has emerged as a vital tool for assessing the safety and potential toxicity of chemotherapy drugs, targeted therapies, and experimental treatments. Researchers can closely evaluate the impact on the animals' health by administering substances to laboratory animals, such as mice and rats. The surge in lung cancer cases has thus created a compelling need for new treatment options, prompting intensified drug development efforts. This intensified pursuit of treatments is expected to catalyze the in vivo toxicology testing market as pharmaceutical companies and researchers strive to ensure the safety of their innovations, consequently reshaping the toxicology testing industry during the forecast period in the region.

Additionally, by product type, consumables accounted for the largest share globally in 2022. In vivo, toxicology entails the investigation of how chemicals or substances negatively affect living organisms. Conversely, consumables encompass products with a short lifespan that require frequent replacement, including reagents, kits, and test systems. Given the pharmaceutical sector's continuous strides in novel drug creation, in vivo, toxicology testing is a pivotal facet of the drug development journey. Consequently, there has been a noticeable uptick in the requirement for consumables essential to facilitate these crucial tests. Also, by toxicity endpoint, the immunotoxicity segment is the largest shareholder.

By end-user, academic & research institutes segment accounted for the largest share in 2022. Academic and research institutions play a critical role in conducting comprehensive research efforts encompassing drug development, toxicity assessment, and fundamental scientific investigations. In vivo toxicology testing holds a significant position within this spectrum, contributing substantially to these research initiatives. Consequently, a notable escalation in the need for in vivo toxicology testing services has arisen, driven by its imperative role in advancing scientific knowledge and facilitating the development of innovative solutions.

Drivers for In Vivo Toxicology Market:

Technological advancements have increasingly helped researchers to gain insights into toxicity mechanisms, supporting a greater understanding of species relevance and translatability to humans, prediction of safety affairs, mitigating of side effects and developing safety biomarkers. The elevated insight accelerates the detection of potential safety concerns and empowers the strategic alleviation of unwanted side effects, significantly expediting drug development. As technology-driven revelations continue to unfold, the capacity to unravel intricate toxicity intricacies offers a transformative impetus to enhance human health and product safety. Therefore, technological advances are expected to propel the market growth.

Restrain for In Vivo Toxicology Market:

The ethical concern associated with using animals for toxicological testing has sparked debates and drawn attention to the welfare of animal studies. As awareness and sympathy for animal rights have increased, there has been an increasing call for reducing, refining and replacing animal testing procedures. This belief has translated into public and regulatory pressures aimed at minimizing or eliminating the reliance on animal testing in favor of more humane and scientifically advanced alternatives. The stringent regulatory guidelines and scrutiny on in vivo toxicology practices loom over the market as stakeholders navigate the delicate balance between scientific advancement, safety assessments, and the ethical treatment of animals, further impeding the market's growth.

Opportunities for In Vivo Toxicology Market:

Recent advancements in in-vivo toxicology to improve the predictive value of investigative toxicology assay are in iPSCs (induced pluripotent stem cells), 3D tissue models, advanced micro-physiological systems (MPS), and high-resolution imaging techniques. iPSC provides a renewable and patient-specific cell source for toxicity analyses, while 3D tissue models mimic complex organ structures, allowing more physiologically appropriate assessments. MPS, including organ-on-a-chip platforms, replicate dynamic cellular interactions and organ function, enabling real-time monitoring of toxic reactions. Additionally, high-resolution imaging provides detailed insights into cellular behavior and tissue morphology. Leveraging these advancements presents opportunities for drug development, reduced reliance on traditional animal testing, and the potential to revolutionize safety assessment, reinforcing the in vivo toxicology market and further dominating the market growth.

Trend for In Vivo Toxicology Market:

Data integration and computational modeling have emerged as crucial trends in the field of in vivo toxicology and are expected to be significant drivers in market growth. The convergence of in vivo toxicity data, in vitro experimental results, and computational models has gained prominence, enabling multifaceted insights into toxicity mechanisms and effects. This trend responds to the growing need for comprehensive risk evaluation by leveraging diverse data sources to improve accuracy and decision-making across drug development, chemical safety assessment, and environmental monitoring. As these technologies continue to evolve, integrating these data types offers the potential to revolutionize toxicity assessments, reducing reliance on traditional animal testing.

  • Tier 1 players- established companies in the market with a major market share
  • Tier 2 players
  • Emerging players which are growing rapidly
  • New Entrants

  • FutureWise research report will help you understand the growth prospects, key trends, and data points affecting the market's growth.
  • A detailed review of strategies being opted by the players in this market, and a thorough market share registered by the key companies globally as well as on a regional basis.

  • To provide with an exhaustive analysis on the of In Vivo Toxicology Market By Product, By Test Type, By Testing Facility, By Toxicity Endpoint, By End-user and By Region.
  • To cater comprehensive insights on factors such as drivers, restraints, trends, opportunity, and additionally segmental and regional factors impacting market growth.
  • To evaluate current market trends and forecast micro-markets and the overall market projections which are represented in the format of data-sets and ppt.
  • To predict the market size, in key regions— North America, Europe, Asia Pacific, Latin America and Middle East and Africa. 
  • To provide information on competitors which includes landscape mapping, technological advancements, R&D spending, news concerning strategic alliances, and new product launches.

  • We have a flexible delivery model and you can suggest changes in the scope/table of content as per your requirement
  • The customization Mobility Care offered are free of charge with purchase of any license of the report
  • You can directly share your requirements/changes to the current table of content to: sales@futurewiseresearch.com

Table of Contents


  • 1.   Market Introduction
    •   1. Objectives of the Study
        2. Market Definition
        3. Market Scope
         3.1. Years Considered for the Study
         3.2. Market Covered
        4. Currency
        5. Limitations
        6. Stakeholders
  • 2.   Research Methodology
    •   1. Research Data
         1.1. Secondary Data
          1.1.1. Key Data from Secondary Sources
         1.2. Primary Data
          1.2.1. Key Data from Primary Sources
        2. Market Size Estimation
        3. Market Breakdown and Data Triangulation
        4. Assumptions for the Study
  • 3.   Executive Summary
    •   1. Market Outlook
        2. Segment Outlook
        3. Competitive Insights
  • 4.   In-Vivo Toxicology Market Variables, Trends and Scope
    •   1. Market Lineage Outlook
        2. Penetration and Growth Prospect Mapping
        3. Industry Value Chain Analysis
        4. Cost Analysis Breakdown
        5. Technology Overview
        6. Regulatory Framework
         6.1. Reimbursement Framework
         6.2. Standards and Compliances

  • 5.   Market Overview
    •   1. Market Dynamics
         1.1. Market Driver Analysis
          1.1.1. Increasing focus of In-Vivo Toxicology Market Companies on Brand Protection
          1.1.2. Untapped Opportunities in Emerging Regions
         1.2. Market Restraint Analysis
          1.2.1. High Cost Associated with Implementation of Predictive Analysis
         1.3. Industry Challenges
          1.3.1. Presence of Ambiguous Regulatory Framework
  • 6.   In-Vivo Toxicology Market Analysis Tools
    •   1. Industry Analysis - Porter’s
         1.1. Supplier Power
         1.2. Buyer Power
         1.3. Substitution Threat
         1.4. Threat from New Entrants
         1.5. Competitive Rivalry
        2. Pestel Analysis
         2.1. Political Landscape
         2.2. Environmental Landscape
         2.3. Social Landscape
         2.4. Technology Landscape
         2.5. Legal Landscape
        3. Major Deals And Strategic Alliances Analysis
         3.1. Joint Ventures
         3.2. Mergers and Acquisitions
         3.3. Licensing and Partnership
         3.4. Technology Collaborations
         3.5. Strategic Divestments
        4. Market Entry Strategies
        5. Case Studies
  • 7.   In Vivo Toxicology Market, By Product Historical Analysis and Forecast 2023-2031 (USD Million)
    •   1. Instruments
        2. Consumables
         2.1. Reagents and Kits
         2.2. Animal Models
          2.2.1. Mice Models
          2.2.2. Rat Models
          2.2.3. Other Animal Models (Guinea Pigs, Hamsters, Rabbits, and Human Primates)

  • 8.   In Vivo Toxicology Market, By Test Type Historical Analysis and Forecast 2023-2031 (USD Million)
    •   1. Acute
        2. Sub-acute
        3. Sub-chronic
        4. Chronic test type

  • 9.   In Vivo Toxicology Market, By Testing facility Historical Analysis and Forecast 2023-2031 (USD Million)
    •   1. Outsourced testing facility
        2. In-house testing facility

  • 10.   In Vivo Toxicology Market, By Toxicity End Point Historical Analysis and Forecast 2023-2031 (USD Million)
    •   1. Immunotoxicity
        2. Systemic toxicity
        3. Carcinogenicity
        4. Genotoxicity
        5. Developmental and reproductive toxicity (DART)
        6. Other toxicity endpoints

  • 11.   In Vivo Toxicology Market, By End User Historical Analysis and Forecast 2023-2031 (USD Million)
    •   1. Academic and Research Institutes
        2. Pharmaceutical and Biotechnology Companies
        3. Contract Research Organizations
        4. Other End Users

  • 12.   North America In Vivo Toxicology Market Analysis 2017-2022 and Forecast 2023-2031 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2017-2022
         2.1. U.S.A
         2.2. Canada
         2.3. Mexico
        3. Market Size (USD Million) Forecast for North America 2023-2031

  • 13.   Latin America In Vivo Toxicology Market Analysis 2017-2022 and Forecast 2023-2031 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2017-2022
         2.1. Brazil
         2.2. Venezuela
         2.3. Argentina
         2.4. Rest of Latin America
        3. Market Size (USD Million) Forecast for Latin America 2023-2031

  • 14.   Europe In-Vivo Toxicology Market Analysis 2017-2022 and Forecast 2023-2031 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2017-2022
         2.1. Germany
         2.2. U.K
         2.3. France
         2.4. Italy
         2.5. Spain
         2.6. Russia
         2.7. Poland
         2.8. Rest of Europe
        3. Market Size (USD Million) Forecast for Europe 2023-2031

  • 15.   Asia Pacific In-Vivo Toxicology Market Analysis 2017-2022 and Forecast 2023-2031 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2017-2022
         2.1. Japan
         2.2. China
         2.3. India
         2.4. Australia and New Zealand
         2.5. ASEAN
         2.6. Rest of Asia Pacific
        3. Market Size (USD Million) Forecast for Asia Pacific 2023-2031

  • 16.   Middle East and Africa Market Analysis 2017-2022 and Forecast 2023-2031 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2017-2022
         2.1. GCC
         2.2. Israel
         2.3. South Africa
         2.4. Rest of MEA
        3. Market Size (USD Million) Forecast for MEA 2023-2031

  • 17.   Market Share Analysis and Competitive Landscape
    •   1. Global Landscape - Key Players, Revenue and Presence
        2. Global Share Analysis - Key Players (Tier 1, Tier 2, Tier 3)
        3. Global Emerging Companies
        4. North America - Market Share Analysis and Key Regional Players
        5. Europe - Market Share Analysis and Key Regional Players
        6. Asia Pacific - Market Share Analysis and Key Regional Players
        7. Global Key Player - Growth Matrix
  • 18.   Company Profiles (Competition Dashboard, Competitors Deep Dive, Products Offered and Financial Layouts)
    •   1. Thermo Fisher Scientific
         1.1. Company Overview
         1.2. Product Portfolio
         1.3. SWOT Analysis
         1.4. Financial Overview
         1.5. Strategic Overview
        2. Danaher
         2.1. Company Overview
         2.2. Product Portfolio
         2.3. SWOT Analysis
         2.4. Financial Overview
         2.5. Strategic Overview
        3. Charles River Laboratories
         3.1. Company Overview
         3.2. Product Portfolio
         3.3. SWOT Analysis
         3.4. Financial Overview
         3.5. Strategic Overview
        4. Labcorp
         4.1. Company Overview
         4.2. Product Portfolio
         4.3. SWOT Analysis
         4.4. Financial Overview
         4.5. Strategic Overview
        5. The Jackson Laboratory
         5.1. Company Overview
         5.2. Product Portfolio
         5.3. SWOT Analysis
         5.4. Financial Overview
         5.5. Strategic Overview
        6. Data Sciences International
         6.1. Company Overview
         6.2. Product Portfolio
         6.3. SWOT Analysis
         6.4. Financial Overview
         6.5. Strategic Overview
        7. Envigo
         7.1. Company Overview
         7.2. Product Portfolio
         7.3. SWOT Analysis
         7.4. Financial Overview
         7.5. Strategic Overview
        8. Eurofins Scientific
         8.1. Company Overview
         8.2. Product Portfolio
         8.3. SWOT Analysis
         8.4. Financial Overview
         8.5. Strategic Overview
        9. Perkinelmer
         9.1. Company Overview
         9.2. Product Portfolio
         9.3. SWOT Analysis
         9.4. Financial Overview
         9.5. Strategic Overview
        10. SRI International
         10.1. Company Overview
         10.2. Product Portfolio
         10.3. SWOT Analysis
         10.4. Financial Overview
         10.5. Strategic Overview
        11. Taconic Biosciences
         11.1. Company Overview
         11.2. Product Portfolio
         11.3. SWOT Analysis
         11.4. Financial Overview
         11.5. Strategic Overview
        12. Wuxi Apptec
         12.1. Company Overview
         12.2. Product Portfolio
         12.3. SWOT Analysis
         12.4. Financial Overview
         12.5. Strategic Overview

  • 19.   Pre and Post COVID-19 Impact
    •   1. Positive influence on the healthcare industry
        2. The financial disruption of the manufacturing sector
        3. Impact of COVID-19 on emerging companies
        4. Significant mandates in the healthcare regulations initiated by
                  administrations
        5. The overall economic slowdown of the developing and developed nations

  • 20.   FutureWise SME Key Takeaway Points for Client

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